Korean doctor develops technology for monitoring the effect of new drugs in real time using Smart Nano-Sensors
Doctor Sang-Kyu Lee of the Department of Biological Sciences, KAIST, has developed the technology that allows biological nano particles to be implanted into human cells for monitoring the effect of new drugs in real time from within the cell. Conventionally, the candidate drug was injected into the human body, and then its cells are extracted to analyze the effects of the drugs. The problem with this method was that the cells were analyzed at a ‘dead’ state which made it incredibly difficult to find candidate substances due to uncontrollable side effects. This made the development of new drugs very difficult despite the large costs and efforts invested into its development.
The research team latched onto the idea that nanoparticles can connect to form a large complex. The complex acts as a nanosensor which allows for real time observation of drug target and the drug itself binding. The team named the nanosensor technology InCell SMART-I and was named Hot Paper of the September edition of Angewandte Chemie International Edition magazine, a world famous Chemistry Magazine. It is expected that this technology will boost the ability to weigh the effects and properties of a new drug more quickly and accurately.